Published: 21 Oct 2025 15 views
Co-supervised by Dr Kirsty Wilson and Professor Katie Flanagan (UTAS). The presence in sera of pro-inflammatory cytokines has emerged as an aetiological and perpetuating factor for major depression across the lifespan. The immune system of the elderly, and particularly females, displays heightened persistent chronic inflammation or ‘inflammaging’. Mechanistically, it may be caused by epigenetic re-programming of monocytes, resulting in an increased capacity to produce inflammatory factors in response to environmental stimuli, such as bacterial and viral toll-like receptor (TLR) ligands. This interdisciplinary study will examine the relationship between inflammatory status and epigenetic programming of monocytes in relation to depression across different age groups (young and elderly) and sexes (male and female).
Applicants need to have a background in immunology, genetics or bioinformatics. They must have completed a relevant Bachelor’s Degree and Honour’s or Master’s.
Desirable criteria:
To apply, please submit the following documents to Prof. Magdalena Plebanski ([email protected]) and Dr Kirsty Wilson ([email protected]).
For further inquiries please contact Distinguished Professor Magdalena Plebanski ([email protected]) and Dr Kirsty Wilson ([email protected]).
For more information, kindly visit RMIT University scholarship webpage.
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